Basic Information
| LncRNA/CircRNA Name | MDC1-AS |
| Synonyms | MDC1-AS1, MDC1-AS |
| Region | GRCh38_6:30703067-30713184 |
| Ensemble | ENSG00000224328 |
| Refseq | NR_133647 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues, cell lines (KATO III, SGC.7901, AGS, MN45, MKN28, RGM.1) |
| Expression Pattern | down-regulated |
| Function Description | The knockdown of MDC1 relieved the inhibitory effect of MDC1-AS on MKN28 cell proliferation and metastasis, while the overexpression of MDC1 attenuated the stimulatory effect of MDC1-AS knockdown in MKN45 cells. MDC1-AS had an inhibitory on gastric tumorigenesis through an MDC1-dependent mechanism. |
| Pubmed ID | 29375682 |
| Year | 2017 |
| Title | Long non-coding RNA MDC1-AS inhibits human gastric cancer cell proliferation and metastasis through an MDC1-dependent mechanism. |
External Links
| Links for MDC1-AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |