Basic Information
| LncRNA/CircRNA Name | MDC1-AS |
| Synonyms | MDC1-AS1, MDC1-AS |
| Region | GRCh38_6:30703067-30713184 |
| Ensemble | ENSG00000224328 |
| Refseq | NR_133647 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | Microarray, qPCR etc. |
| Sample | bladder cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | The expression levels of MDC1-AS and MDC1 was down-regulated in bladder cancer. After over-expression of MDC1-AS, increased levels of MDC1 were observed in bladder cancer cells. We also found a remarkably inhibitory role of antisense lncRNA MDC1-AS on malignant cell behaviors in bladder cancer cells EJ and T24. |
| Pubmed ID | 25514464 |
| Year | 2014 |
| Title | A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer. |
External Links
| Links for MDC1-AS | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |