Basic Information
| LncRNA/CircRNA Name | MCM3AP-AS1 |
| Synonyms | NA |
| Region | GRCh38_21:46229217-46259390 |
| Ensemble | ENSG00000215424 |
| Refseq | NR_002776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | glioma tissues, GBM cell line U87 |
| Expression Pattern | up-regulated |
| Function Description | lncRNA antisense 1 to Micro-chromosome maintenance protein 3-associated protein (MCM3AP-AS1) was upregulated whereas miR-211 was downregulated in glioma-associated endothelial cells (GECs).Furthermore, knockdown of MCM3AP-AS1 increased the expression of miR-211.miR-211 targeted KLF5 3'-UTR and consequently inhibited KLF5 expression.Besides,in this study we found that MCM3AP-AS1 knockdown decreased KLF5 and AGGF1 expression by upregulating miR-211.In addition, KLF5 was associated with the promoter region of AGGF1.Knockdown of KLF5 decreased AGGF1 expression by transcriptional repression, and also inhibited the activation of PI3K/AKT and ERK1/2 signaling pathways. |
| Pubmed ID | 29375300 |
| Year | 2018 |
| Title | The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis. |
External Links
| Links for MCM3AP-AS1 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |