Basic Information
| LncRNA/CircRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 |
| Ensemble | ENSG00000278910 |
| Refseq | NR_047671 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-PCR , Western blot etc. |
| Sample | NSCLC paraneoplastic tissues and adjacent normal tissues ,NSCLC adenocarcinoma cell lines (A549, SPC-A1,H1299, H1650, H1975, and PC-9) normal human pneumonocytes 16HBE |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of BANCR in these six NSCLC cell lines attenuated the cell viability and invasion. An increased apoptotic level caused by BANCR overexpression was also detected and displayed a conversed influence on Bcl-2 and Bax expression in mRNA and protein level. Furthermore, we identified the effect of BANCR overexpression on tumor growth in NSCLC mouse model. The restoration of BANCR expression inhibits NSCLC. |
| Pubmed ID | 31114383 |
| Year | 2019 |
| Title | lncRNA BANCR Suppresses Cell Viability and Invasion and Promotes Apoptosis in Non-Small-Cell Lung Cancer Cells in Vitro and in Vivo |
External Links
| Links for BANCR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |