Basic Information
| LncRNA/CircRNA Name | MCM3AP-AS1 |
| Synonyms | NA |
| Region | GRCh38_21:46229217-46259390 |
| Ensemble | ENSG00000215424 |
| Refseq | NR_002776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blotting etc. |
| Sample | A total 64 pairs of papillary thyroid cancer tissues and adjacent non-tumor tissue, TPC-1, HTH83, 8505C, SW1736, and BCPAP cell lines |
| Expression Pattern | up-regulated |
| Function Description | In papillary thyroid cancer, MCM3AP-AS1 was upregulated, while miR-211 was downregulated. MCM3AP-AS1 overexpression promoted papillary thyroid cancer proliferation, migration, and invasion. Further, MCM3AP-AS1 was shown to be negatively correlated with miR-211-5p. We next validated that miR-211-5p overexpression could reverse the promoting role of MCM3AP-AS1 in papillary thyroid cancer, whereby SPARC plays an important regulating role. In vivo, we confirmed the anti-tumor role of MCM3AP-AS1 silencing and the close relation among MCM3AP-AS1, miR-211-5p, and SPARC. |
| Pubmed ID | 31030335 |
| Year | 2019 |
| Title | LncRNA MCM3AP-AS1 Promotes Proliferation and Invasion Through Regulating miR-211-5p/SPARC Axis in Papillary Thyroid Cancer |
External Links
| Links for MCM3AP-AS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |