Basic Information
| LncRNA/CircRNA Name | MCM3AP-AS1 |
| Synonyms | MCM3AP antisense RNA 1 |
| Region | GRCh38_21:46229217-46259390 |
| Ensemble | ENSG00000215424 |
| Refseq | NR_002776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, RIP, Luciferase reporter assay, Western blot analysis |
| Sample | lung cancer cell lines A549, H1299, H596, and H520 along with human bronchial epithelial cell BEAS-2B |
| Expression Pattern | up-regulated |
| Function Description | MCM3AP-AS1 expression was found to be elevated in lung cancer cells. Depletion of MCM3AP-AS1 repressed cell proliferation, migration, and angiogenesis in lung cancer cells.the YY1-mediated overexpression of MCM3AP-AS1 accelerated angiogenesis and progression in lung cancer by targeting miR-340-5p/KPNA4 axis. |
| Pubmed ID | 31693222 |
| Year | 2020 |
| Title | YY1-mediated Overexpression of Long Noncoding RNA MCM3AP-AS1 Accelerates Angiogenesis and Progression in Lung Cancer by Targeting miR-340-5p/KPNA4 Axis |
External Links
| Links for MCM3AP-AS1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |