Basic Information
| LncRNA/CircRNA Name | MCM3AP-AS1 |
| Synonyms | NA |
| Region | GRCh38_21:46229217-46259390 |
| Ensemble | ENSG00000215424 |
| Refseq | NR_002776 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, RIP etc |
| Sample | PCa and adjacent normal tissues,cell lines (22RV1, LNCaP, and DU145) |
| Expression Pattern | up-regulated |
| Function Description | MCM3AP-AS1 Is Highly Expressed in PCa.Furthermore, overexpressed MCM3AP-AS1 was observed to facilitate PCa development in vivo, which could be reversed by overexpressed NPY1R. Altogether, MCM3AP-AS1 silencing inhibits PCa progression by disrupting methylation of the NPY1R promoter to inactivate the MAPK pathway. |
| Pubmed ID | 32193153 |
| Year | 2020 |
| Title | MCM3AP-AS1 KD Inhibits Proliferation, Invasion, and Migration of PCa Cells via DNMT1/DNMT3 (A/B) Methylation-Mediated Upregulation of NPY1R |
External Links
| Links for MCM3AP-AS1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |