Basic Information
| LncRNA/CircRNA Name | MBNL1-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:152262616-152269555 |
| Ensemble | ENSG00000229619 |
| Refseq | NR_027037 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | The colon cancer cell line HT29 |
| Expression Pattern | down-regulated |
| Function Description | MBNL1-AS1 and MYL9 were poorly expressed in colon cancer. MBNL1-AS1 could competitively bind to miR-412-3p so as to promote MYL9 expression. Enhancement of MBNL1-AS1 or inhibition of miR-412-3p was shown to decrease CSC proliferation, migration, and invasion but promote apoptosis. Moreover, MBNL1-AS1 reversed the CSC-like properties as well as xenograft tumor formation in vivo induced by miR-412-3p. |
| Pubmed ID | 31255531 |
| Year | 2019 |
| Title | Long non-coding RNA MBNL1-AS1 regulates proliferation, migration, and invasion of cancer stem cells in colon cancer by interacting with MYL9 via sponging microRNA-412-3p |
External Links
| Links for MBNL1-AS1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |