Basic Information
| LncRNA/CircRNA Name | MBNL1-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:152262616-152269555 |
| Ensemble | ENSG00000229619 |
| Refseq | NR_027037 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | NSCLC and adjacent normal tissues ,human normal lung epithelial cell line BEAS-2B and NSCLC cell lines (A549, H1299, and SK-MES-1) |
| Expression Pattern | down-regulated |
| Function Description | Initially, the intersection among lncRNA MBNL1-AS1, miR-301b-3p, and TGFBR2 was observed in NSCLC. While a poor expression of lncRNA MBNL1-AS1 and TGFBR2, along with a high expression of miR-301b-3p was observed in NSCLC tissues.A demonstration of lncRNA MBNL1-AS1 restoration significantly decreased CSC proliferation, migration, invasion, drug resistance, and sphere formation in NSCLC.MBNL1-AS1 functioned as a sponge of miR-301b-3p, which inverted the inhibitory role of lncRNA MBNL1-AS1 in CSC proliferation, migration, invasion, drug resistance, and sphere formation in NSCLC.At last, upregulated lncRNA MBNL1-AS1 or depleted miR-301b-3p suppressed the xenograft tumor formation in vivo. |
| Pubmed ID | 31113460 |
| Year | 2019 |
| Title | microRNA-301b-3p Downregulation Underlies a Novel Inhibitory Role of Long Non-Coding RNA MBNL1-AS1 in Non-Small Cell Lung Cancer |
External Links
| Links for MBNL1-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |