Basic Information
| LncRNA/CircRNA Name | MBNL1-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:152262616-152269555 |
| Ensemble | ENSG00000229619 |
| Refseq | NR_027037 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | bladder cancer tissues ,cell lines (5637, SW780, and UMUC3) |
| Expression Pattern | differential expressed |
| Function Description | MBNL1-AS1 and QKI could directly bind with miR-362-5p, and knockdown of MBNL1-AS1 or QKI could abrogate the regulatory effects of miR-362-5p on bladder cancer cell proliferation. Furthermore, downregulation of miR-362-5p inhibited bladder tumor growth and increased QKI expression. |
| Pubmed ID | 32194406 |
| Year | 2020 |
| Title | MiR-362-5p, Which Is Regulated by Long Non-Coding RNA MBNL1-AS1, Promotes the Cell Proliferation and Tumor Growth of Bladder Cancer by Targeting QKI |
External Links
| Links for MBNL1-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |