Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assays etc. |
| Sample | TNBC tissues, cell lines (MDA-MB-231, MDA-MB-453, MCF-7, TB- 549, BT-474) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 inhibition significantly induced cell cycle arrest in the G0/G1 phase. the roles of MALAT1 on TNBC cells progression was mediated by miR-129-5p. the ??ALAT1-miR-129-5p??axis might play an important role in the progression of TNBC, thereby might provide a potential therapeutic strategy for the treatment of TNBC. patients with high MALAT1 expression had a poor overall survival compared to patients with low MALAT1 expression. |
| Pubmed ID | 28915533 |
| Year | 2017 |
| Title | Long non-coding RNA MALAT1 promotes proliferation and invasion via targeting miR-129-5p in triple-negative breast cancer |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |