Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, Dual luciferase reporter assay etc. |
| Sample | breast cancer tissues, cell lines (MCF-7, Bcap-37 and MDAMB-435S) |
| Expression Pattern | up-regulated |
| Function Description | We also found that MALAT1 was increased in most breast cancer cells. In contrast, miR-124 was downregulated in the MCF-7 cells with MALAT1 overexpression. We found that MALAT1 expression had no effect in breast cancer cells treated with the miR-124 mimic or miR-124 inhibitor. Taken together, our results reveal that MALAT1 may act as an endogenous potent regulator that reduces miR-124 expression. |
| Pubmed ID | 26918449 |
| Year | 2016 |
| Title | miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |