Basic Information
| LncRNA/CircRNA Name | BACE1-AS |
| Synonyms | BACE1-AS, BACE1-AS1, BACE1AS, NCRNA00177 |
| Region | GRCh38_11:117290874-117293571 |
| Ensemble | ENSG00000278768 |
| Refseq | NR_037803 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Northern blot, MTT assay etc. |
| Sample | ovarian cancer stem cell |
| Expression Pattern | up-regulated |
| Function Description | The mRNA expression levels of BACE1-AS were significantly increased in anisomycin-treated OCSCs compared to controls. In addition, mRNA and protein levels of BACE1 and AB1-42 were increased in anisomycin-treated OCSCs compared to controls. We confirmed that anisomycin suppressed the growth of xenograft tumors formed by OCSCs in vivo. Finally, when expression of lncRNA BACE1-AS was silenced using siRNA, BACE1 expression was downregulated and the antiproliferative and anti-invasive effects of anisomycin were reduced. |
| Pubmed ID | 26783004 |
| Year | 2016 |
| Title | Long non-coding RNA BACE1-AS is a novel target for anisomycin-mediated suppression of ovarian cancer stem cell proliferation and invasion. |
External Links
| Links for BACE1-AS | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |