Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | cell line (HeLa) |
| Expression Pattern | up-regulated |
| Function Description | The levels of MALAT1 were also significantly higher in the MALAT1 transfection group compared to the control group. Low levels of miRNA-143 and high levels of MALAT1 could potentiate proliferation of the cervical cancer cell line HeLa, and accelerate its invasion and migration via enhancement of vimentin and reduction of E-cadherin levels, respectively. |
| Pubmed ID | 28252165 |
| Year | 2017 |
| Title | Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |