Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (DU145 and PC3, HEK-293T), PCa tissues |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 expression levels were up-regulated in clinical DTX-resistant PCa samples.Overexpressed MALAT1 promoted cell proliferation,migration and invasion but decreased cell apoptosis rate of PCa cells in spite of DTX treatment.We identified miR-145-5p as a target of MALAT1.MiR-145-5p overexpression in PC3-DTX led to inhibited cell proliferation, migration and invasion as well as reduced chemoresistance to DTX,which was attenuated by MALAT1.Moreover,we determined that AKAP12 was a target of miR-145-5p,which significantly induced chemoresistance of PCa cells to DTX. Besides,it was proved that MALAT1 promoted tumour cell proliferation and enhanced DTX-chemoresistance in vivo. |
| Pubmed ID | 29633510 |
| Year | 2018 |
| Title | Long noncoding RNA MALAT1 enhances the docetaxel resistance of prostate cancer cells via miR-145-5p-mediated regulation of AKAP12. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |