Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | bladder cancer tissues, cell lines (T24, RT4 etc.) |
| Expression Pattern | up-regulated |
| Function Description | TGFB1 induces malat1 expression and EMT in bladder cancer cells. malat1 overexpression is significantly correlated with poor survival in patients with bladder cancer. malat1 and E-cadherin expression is negatively correlated in vitro and in vivo. malat1 knockdown inhibits TGFB1 induced EMT. malat1 is associated with suz12, and this association results in decrease of E-cadherin expression and increase of N-cadherin and fibronectin expression. Targeted inhibition of malat1 or suz12 suppresses the migratory and invasive properties induced by TGFB1 We demonstrated that malat1 or suz12 knockdown inhibits tumor metastasis in animal models. |
| Pubmed ID | 24449823 |
| Year | 2014 |
| Title | TGFB1 induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |