Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | Microarray, RT-PCR, Western blot, in vitro knockdown, RNAi |
| Sample | mice tissues heartlungs, diaphragm, pancreas, liver, kidney, spleen, stomach, small intestine, large intestine, testis/ovaries and brain, cell lines (Panc28, L3.6pL, HPDE, Panc1, ASPC1, BxPC3 and MiaPaCa2) |
| Expression Pattern | up-regulated |
| Function Description | we show that knockdown of MALAT-1 in Panc1 and other pancreatic cancer cell lines decreases cell proliferation, survival and migration.Analysis of changes in gene expression after MALAT-1 knockdown shows that this lncRNA represses several tumor suppressor-like genes including N-myc downregulated gene-1 (NDRG-1), a tumor suppressor in pancreatic cancer that is also corepressed by EZH2 (a PRC2 complex member).We also observed that Specificity proteins Sp1, Sp3 and Sp4 are overexpressed in Panc1 cells and Sp knockdown or treatment with small molecules that decrease Sp proteins expression also decrease MALAT-1 expression. |
| Pubmed ID | 29389953 |
| Year | 2018 |
| Title | Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |