Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | neuroblastoma tissues, cell lines (NGP, SHSY5Y, NMB, SHEP21N, SKNAS, and SHEP2) |
| Expression Pattern | differential expression |
| Function Description | Meanwhile, our data suggested that metastasis-associated lung adenocarcinoma transcript 1 upregulated Axl expression in neuroblastoma cells, resulting in cell invasion and migration. Furthermore, we found that targeting Axl by inhibitor R428 significantly suppressed the abilities of tumor cell invasion and migration. |
| Pubmed ID | 28468579 |
| Year | 2017 |
| Title | LncRNA-MALAT1-mediated Axl promotes cell invasion and migration in human neuroblastoma |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |