Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | Microarray, qPCR etc. |
| Sample | cell lines (UMR-106 and PC3) |
| Expression Pattern | up-regulated |
| Function Description | The qPCR data showed a ~6-fold increase in MALAT1 expression in PC3 cells co-cultured with UMR osteoblasts compared to PC3 monocultures. Treatment with recombinant SOST resulted in ~5.6-fold reduction in MALAT1 expression, suggesting that Sost in the tumor microenvironment may have an inhibitory effect on MALAT1 and down-regulation of Sost in the bone microenvironment may enhance MALAT1 expression in prostate cancer. |
| Pubmed ID | 27600237 |
| Year | 2016 |
| Title | Cancer-Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |