Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR etc. |
| Sample | cell line (SK-N-SH) |
| Expression Pattern | down-regulated |
| Function Description | We identified a shorter transcriptional initiation site and found that CREB binds to the defined proximal promoter of the MALAT1 gene. The expression of the tumor marker MALAT1 ncRNA is sensitive to cell surface receptor activation by oxytocin in a neuroblastoma cell line. |
| Pubmed ID | 20149803 |
| Year | 2010 |
| Title | Oxytocin stimulates expression of a noncoding RNA tumor marker in a human neuroblastoma cell line. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |