Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Cell proliferation assay etc. |
| Sample | esophageal cancer tissues, cell lines (EC109, KYSE150, HEF-1A) |
| Expression Pattern | up-regulated |
| Function Description | Expression levels of MALAT1 were significantly higher in EC tissues and cells than the controls. MALAT1 expression was tightly related to lymphatic invasion, distant metastasis and tumor differentiation, but shared no association with age, gender and tumor location. In addition, patients with high MALAT1 expression had a shorter overall survival than those with low MALAT1. |
| Pubmed ID | 27470544 |
| Year | 2016 |
| Title | Increased MALAT1 expression predicts poor prognosis in esophageal cancer patients. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |