Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrioid endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | EEC tissues, cell lines (RL-952, HEC-1-B and JEC) |
| Expression Pattern | down-regulated |
| Function Description | In the present study, we first showed that miR-200c levels were higher in most EEC specimens than in non-tumor tissues, while MALAT1 levels were lower. Moreover, we found that miR-200c bound directly to MALAT1 using luciferase reporter and qRT-PCR assays. MALAT1 and miR-200c are reciprocally repressed, and TGF-B increased MALAT1 expression by inhibiting miR-200c. When the interaction between miR-200c/MALAT1 was interrupted, the invasive capacity of EEC cells was decreased and EMT markers expression were altered in vitro. |
| Pubmed ID | 27693631 |
| Year | 2016 |
| Title | Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for endometrioid endometrial cancer | OMIM COSMIC |