Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue cancer |
| ICD-0-3 | C02 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, MTT assay etc. |
| Sample | tongue cancer tissues, cell lines (CAL-27, SCC-9, SCC-4, SCC-15 and SCC-25) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was specifically upregulated in tongue cancer cell lines and overexpression promoted tongue cancer cell growth by targeting miR-124. Knockdown of MALAT1 suppressed the growth and invasion of human tongue cancer cells and inhibited metastasis in vitro and in vivo. In addition, miR-124-dependent jagged1 (JAG1) regulation was required for MALAT1-induced tongue cancer cell growth. |
| Pubmed ID | 28260102 |
| Year | 2017 |
| Title | Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for tongue cancer | OMIM COSMIC |