Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (Y79, Weri-Rb1, SO-Rb50 and HXO-RB44) |
| Expression Pattern | up-regulated |
| Function Description | Through direct targeting miR-124,MALAT1 promotes retinoblastoma cell autophagy.Further,we investigated whether Syntaxin 17 (STX17),a Soluble NSF Attachment Protein receptor (SNARE) of the autophagosome,is involved in MALAT1/miR-124 regulation of retinoblastoma cell autophagy, and the underlying mechanism. |
| Pubmed ID | 29073720 |
| Year | 2018 |
| Title | MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |