Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatoblastoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, PCR etc. |
| Sample | HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | HCC and HPBL have clearly different patterns of gene expression, with genes IGF2, Fibronectin, DLK1, TGFb1, MALAT1 and MIG6 being over-expressed in HPBL versus HCC. In addition, specific areas of the genome appear unstable in HCC, with the same regions undergoing either deletion or increased gene dosage in all HCC. |
| Pubmed ID | 17006932 |
| Year | 2006 |
| Title | Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for hepatoblastoma | OMIM COSMIC |