Basic Information
| LncRNA/CircRNA Name | AWPPH |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, other |
| Sample | colorectal adenocarcinoma cell line (HT-29), serum |
| Expression Pattern | up-regulated |
| Function Description | It was observed that serum levels of lncRNA AWPPH and GLUT-1 were significantly higher in patients with colon cancer patients compared with healthy controls. Serum levels of AWPPH and GLUT-1 were significantly positively correlated in patients with colon cancer. Serum levels of lncRNA AWPPH were associated with the tumor size. Furthermore, AWPPH-silencing significantly inhibited GLUT-1 expression and inhibited cancer cell proliferation. GLUT-1 overexpression promoted cancer cell proliferation and attenuated the inhibitory effects of AWPPH-silencing on cancer cell proliferation. However, GLUT-1 overexpression failed to significantly affect the expression of AWPPH. |
| Pubmed ID | 31423271 |
| Year | 2019 |
| Title | Downregulation of lncRNA AWPPH Inhibits Colon Cancer Cell Proliferation by Downregulating GLUT-1 |
External Links
| Links for AWPPH | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |