Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | myeloma |
| ICD-0-3 | C42.1 |
| Methods | qPCR, RNAi etc. |
| Sample | cell line (RPMI8226, U266) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was found to be highly expressed in RPMI8226 and U266 cells. Down-regulation of MALAT1 via RNA interference significantly inhibited the proliferation of MM cells through cell cycle arrest at G1 phase. Moreover, knockdown of MALAT1 induced apoptosis, which was closely associated with the activation of caspase-3/-9, down-regulation of Bcl-2 and up-regulation of Bax. In addition, silencing of MALAT1 by intratumoral injection of MALAT1 shRNA attenuated the tumor growth in mice bearing myeloma xenograft and led to massive apoptosis in the xenograft tumor. Therefore, MALAT1 may serve as a promising target in the genetic therapeutic strategy for MM treatment. |
| Pubmed ID | 28664617 |
| Year | 2017 |
| Title | Down-regulation of long noncoding RNA MALAT1 by RNA interference inhibits proliferation and induces apoptosis in multiple myeloma |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for myeloma | OMIM COSMIC |