Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Ewing sarcoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Cell transfection, ChIP, Luciferase reporter assay etc. |
| Sample | cell lines (SKNMC, A673, TC32, TC71, SKES1, EW8, TTC-446, EWS502 and CADO-106 ES1) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 is highly 267 expressed both in EWS tumor tissues and cell lines. MALAT1 was identified to be dependent on SYK-mediated signaling. Moreover, c-MYC, a SYK-promoted gene, bound to the promoter of MALAT1 and transcriptionally activated MALAT1, which further promoted the proliferation of EWS cells. |
| Pubmed ID | 28336564 |
| Year | 2017 |
| Title | Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for Ewing sarcoma | OMIM COSMIC |