Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, in vitro knockdown |
| Sample | Breast cancer cell lines (MDA-MB-231, MCF7), and the non-tumorigenic cell line MCF10A, Breast cancer tissues, non-cancerous tissues, Breast cancer tissues, non-cancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | Down-regulation of TALAM1 was shown to greatly impact on the capacity of breast cancer cells to migrate in vitro or to populate the lungs of immunocompromised mice. Additionally, we demonstrated that TALAM1 cooperates with MALAT1 in the regulation of the properties guiding breast cancer aggressiveness and malignancy.Strand-specific detection of MALAT1 and TALAM1 shown that both lncRNAs are significantly upregulated in all breast cancer cell lines tested comparing to the non-tumorigenic cell line |
| Pubmed ID | 31382922 |
| Year | 2019 |
| Title | An antisense transcript mediates MALAT1 response in human breast cancer |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |