Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Multiple myeloma |
| ICD-0-3 | C42.1 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | Human bone marrow stromal cell lines HS-5, Human myeloma cell lines U266, MM.1S, RPMI8226, tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA MALAT1 was increased in MM cells and LncRNA MALAT1 interference could inhibit cell proliferation and promote cell apoptosis with the changes in the related proteins. Also, LncRNA MALAT1 interference could inhibit cell adhesion through HippoYAP signaling pathway. MiR-181a-5p was demonstrated to be a target of LncRNA MALAT1 and miR-181a-5p overexpression could also regulate the changes in cellular behavior in accordance with the LncRNA MALAT1 interference. In addition, LncRNA MALAT1 interference could decrease the expression of miR-181a-5p and inhibit the growth of tumor. |
| Pubmed ID | 31397203 |
| Year | 2019 |
| Title | LncRNA MALAT1/miR-181a-5p Affects the Proliferation and Adhesion of Myeloma Cells via Regulation of Hippo-YAP Signaling Pathway |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for Multiple myeloma | OMIM COSMIC |