Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | HCC tissues, cell lines HepG2, HuH7, and HEK293T |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 expression was upregulated in HCC tissues and positively correlated with Slug expression. MALAT1 and miR 124 3p bind directly and reversibly to each other. MALAT1 silencing inhibited cell migration and invasion. miR 124 3p inhibited HCC metastasis by targeting Slug. Conclusions: MALAT1 regulates Slug through miR 124 3p, affecting HCC cell metastasis. Thus, the MALAT1/miR 124 3p/Slug axis plays an important role in HCC. |
| Pubmed ID | 31466138 |
| Year | 2019 |
| Title | miR-124-3p availability is antagonized by LncRNA-MALAT1 for Slug-induced tumor metastasis in hepatocellular carcinoma |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |