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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	cervical cancer
ICD-0-3	C53
Methods	qPCR, Western blot, Luciferase reporter assay, etc.
Sample	cervical tissues (CC tissues), Human normal cervical epithelial cells H8, human CC cells HeLa, and SiHa
Expression Pattern	up-regulated
Function Description	the expression of periostin was overexpressed in CC tissues and CC cell lines (HeLa and SiHa). Knockdown of periostin in HeLa or SiHa cells significantly decreased cell viability, cell migration and invasion, and reduced epithelial mesenchymal transition (EMT). Moreover, periostin knockdown suppressed the activation of Akt/the mammalian target of rapamycin (mTOR) signaling pathway, which is crucial for periostin to regulate the above biological activities in CC cells. Furthermore, we found that the periostin expression was positively correlated with the expression of metastasis associated lung adenocarcinoma transcript 1 (MALAT1), and negatively correlated with the expression of microRNA (miR) 202 3p in CC tissues. We confirmed that MALAT1 positively regulated the expression of periostin by negatively modulating miR 202 3p. In addition, the MALAT1/miR 202 3p/periostin axis was deeply associated with the regulation of the cell viability, cell migration and invasion, and EMT in CC cells.
Pubmed ID	30633360
Year	2019
Title	Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1/microRNA-202-3p/periostin axis modulates invasion and epithelial-mesenchymal transition in human cervical cancer.

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