Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, other |
| Sample | BC tissues and cell lines (MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | Then, we knocked down endogenous MALAT1 in MCF-7 cells using MALAT1 short hairpin RNA (shRNA). The results revealed that MALAT1 knockdown could significantly inhibit proliferation, migration, and tube formation in vitro. In addition, miR-145 expression inversely changed in BC tissue cases. Furthermore, knockdown of endogenous MALAT1 significantly increased miR-145 levels in MCF-7 cells. This finding indicated an interaction between MALAT1 and miR-145. In addition, knockdown of MALAT1 significantly reduced the expression of vascular endothelial growth factor in MCF-7 cells. |
| Pubmed ID | 30226550 |
| Year | 2018 |
| Title | MALAT1 Promotes Angiogenesis of Breast Cancer |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |