Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | clear cell renal carcinoma tissues, cell lines (ACHN, Caki-1,786-O, HK-2) |
| Expression Pattern | up-regulated |
| Function Description | we observed that MALAT-1 expression is significantly higher in ccRCC compared to normal tissues. miR-182-5p targets MALAT-1 and decreases its expression in cell lines. |
| Pubmed ID | 30037856 |
| Year | 2018 |
| Title | Elevated miR-182-5p Associates With Renal Cancer Cell Mitotic Arrest Through Diminished MALAT-1 Expression. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |