Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase assay, Western blot |
| Sample | cell lines (MG63, Saos-2, U2OS, KHOS, hFOB 1.19, HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | we observed that lncRNA metastasis-associated lung adenocarcinoma transcription 1 (MALAT1) was remarkably overexpressed in osteosarcoma. it was exhibited that knockdown of MALAT1 was able to inhibit osteosarcoma cell proliferation, MALAT1 can function as a competing endogenous RNA by sponging miR-206. It was exhibited that LV-shMALAT1 was able to induce osteosarcoma cell apoptosis in vitro |
| Pubmed ID | 30076726 |
| Year | 2018 |
| Title | MALAT1 Induces Osteosarcoma Progression by Targeting miR-206/CDK9 Axis. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |