Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Dual luciferase reporter assay |
| Sample | colon cancer tissues, cell lines (HCT116, SW480) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was significantly upregulated in CC tissues. reciprocal abolishment of the effects of miR663a overexpression and MALAT1 activation on the proliferation, migration, and invasion of cancer cells was also observed. miR663a and MALAT1 may consist of a negative feedback loop to determine their roles in CC development. |
| Pubmed ID | 30154407 |
| Year | 2018 |
| Title | MALAT1-miR663a negative feedback loop in colon cancer cell functions through direct miRNA-lncRNA binding. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |