Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | anaplastic thyroid cancer |
| ICD-0-3 | C73 |
| Methods | qRT-PCR etc. |
| Sample | Human ATC cell lines(C643 and SW1736) ,BI-847325 |
| Expression Pattern | down-regulated |
| Function Description | MALAT1 gene expression following BI-847325 treatment was significantly downregulated in C643 and SW1736 cell lines.Reversely, miR-363-3p expression was significantly upregulated by BI-847325 in both ATC cell lines.BI-847325 which inhibits both MEK and Aurora kinase family could be effective against ATC by regulating the genes involved in cell cycle and apoptosis including MALAT1and its downstream genes. MALAT1 is a negative regulator of Mcl1 mRNA by sponging of miR-363-3p.MALAT1 leads to Axin1 and APC downregulation and Wnt/?-catenin signaling pathway activation. Stable ?-catenin translocates from the cytoplasm to the nucleus and promotes cyclin D1 gene expression. |
| Pubmed ID | 31077090 |
| Year | 2019 |
| Title | Transcript-level Regulation of MALAT1-mediated Cell Cycle and Apoptosis Genes Using Dual MEK/Aurora Kinase Inhibitor "BI-847325" on Anaplastic Thyroid Carcinoma |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for anaplastic thyroid cancer | OMIM COSMIC |