Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | adrenocortical carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | ACC and normal adrenal cortex (NAC) tissues ,ACC H295R cell line (CRL-2128) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 as overexpressed in ACC.miR-497 post-transcriptionally repressed MALAT1 while MALAT1 also competes for miR-497 binding to its molecular target, EIF4E.Overexpression of miR-497 and silencing of MALAT1 suppressed cellular proliferation and induced cell cycle arrest through downregulation of EIF4E expression.Furthermore, MALAT1 directly binds to SFPQ protein, indicating its multifaceted roles in ACC pathophysiology. |
| Pubmed ID | 31085769 |
| Year | 2019 |
| Title | Reciprocal Interplay of miR-497 and MALAT1 Promotes Tumourigenesis of Adrenocortical Cancer |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for adrenocortical carcinoma | OMIM COSMIC |