Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | metastasis-associated lung adenocarcinoma transcript 1 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot, Dual luciferase reporting assay |
| Sample | LO2 cells, HepG2 cells, Huh-7 cells, THP-1 cells, human umbilical vein endothelial cells (HUVECs),HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | the expression of MALAT1 and VEGF-A was significantly increased in HCC cells. Knockdown of MALAT1 in HCC cells suppressed the production of VEGF-A, impaired the angiogenesis of HUVECs, and facilitated the polarization of macrophage toward the M1 subset.the interaction between MALAT1 and miR-140 or between miR-140 and VEGF-A was confirmed by multiple assays. |
| Pubmed ID | 31693399 |
| Year | 2020 |
| Title | Long Non-Coding RNA MALAT1 Promotes Angiogenesis and Immunosuppressive Properties of HCC Cells by Sponging miR-140 |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |