Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | metastasis-associated lung adenocarcinoma transcript 1 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-qPCR, Western blottin |
| Sample | GC tissues,gastric epithelial cell line GES-1 and the GC cell line MKN45,astric adenocarcinoma-derived circulating tumor cell lines CTC141 and CTC105 |
| Expression Pattern | up-regulated |
| Function Description | To the best of our knowledge, the present study was the first to demonstrate that upregulated MALAT1 was associated with increased autophagy activation in GC tissues. Furthermore, this study reported that MALAT1 increased cell proliferation and enhanced autophagy activation in GC cells. |
| Pubmed ID | 31897197 |
| Year | 2020 |
| Title | Long Non-Coding RNA MALAT1 Activates Autophagy and Promotes Cell Proliferation by Downregulating microRNA-204 Expression in Gastric Cancer |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |