Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | Metastasis-associated lung adenocarcinoma transcript 1 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, Western blot |
| Sample | tumor tissues,normal lung epithelial cells (BEAS-2B) (CRL-9609, ATCC, VA, USA), human bronchial epithelioid cells (HBE),human alveolar epithelial cells (HPAEpiC,A549,H1299 and PG49) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA MALAT1 had high expression in human LAC tissues (vs. paracancerous normal tissue) and human lung adenocarcinoma cells (vs. human normal lung tissue cells). The expression of lncRNA MALAT1 was significantly associated with human lung adenocarcinoma tumor size, lymph node metastasis, and TNM staging, and was negatively correlated with miR-429 expression in lung adenocarcinoma tissues. In vitro, LncRNA MALAT1 could block human LAC cells in the G1 phase to inhibit proliferation by reducing the expression of cyclin D1 protein. LncRNA MALAT1 could inhibit the invasion and migration of human LAC cells by decreasing the expression of MMP-9 and vimentin and increasing the expression of E-cadherin. Malat1 functions as a competing endogenous RNA (ceRNA) for miR-429 and directly suppressed the expression of RhoA protein. |
| Pubmed ID | 31933847 |
| Year | 2019 |
| Title | Long Non-Coding RNA MALAT1 Interaction With miR-429 Regulates the Proliferation and EMT of Lung Adenocarcinoma Cells Through RhoA |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |