Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | metastasis-associated lung adenocarcinoma transcript 1 |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RT-qPCR, Western blot assay, Luciferase assay, RIP |
| Sample | PCa tissues,PCa cell lines (PC-3 and DU145) and human normal prostate epithelial cell line (RWPE-1) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 and BIRC6 were highly expressed in human PCa tumor tissues and cell lines. MALAT1 or BIRC6 knockdown inhibited cell proliferation, migration and invasion and induced cell apoptosis in PCa. MiR-140 could directly bind with MALAT1 or BIRC6 3'UTR. Moreover, MALAT1 knockdown inhibited BIRC mRNA and protein expression through upregulating miR-140 in PCa cells. Additionally, MALAT1 knockdown inhibited PCa xenograft tumor growth by regulating miR-140/BIRC6 axis in vivo. |
| Pubmed ID | 31935634 |
| Year | 2020 |
| Title | MALAT1 Knockdown Inhibits Prostate Cancer Progression by Regulating miR-140/BIRC6 Axis |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |