Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR |
| Sample | breast IDC tissues ,cell line( MCF-12A, MCF-7, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | In summary, we demonstrate for the first time that PNPO and MALAT1 are up-regulated, while miR-216b-5p is down-regulated, in human breast cancer. PNPO is correlated with the overall survival of patients with metastasis at the later stage. MALAT1/miR-216b-5p/PNPO may act as competing endogenous RNAs (ceRNAs) that affect the biological behavior of breast cancer cells and cancer progression. |
| Pubmed ID | 30982780 |
| Year | 2019 |
| Title | Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development. |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |