Basic Information
LncRNA/CircRNA Name | MALAT1 |
Synonyms | NA |
Region | GRCh38_11:65497688-65506516 |
Ensemble | ENSG00000251562 |
Refseq | NR_002819 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | prostate cancer |
ICD-0-3 | C61.9 |
Methods | qPCR etc. |
Sample | prostate cancer tissues, cell lines(PC-3) |
Expression Pattern | down-regulated |
Function Description | We showed for the first time that MALAT1 expression was significantly downregulated in quercetin-treated PC cells in a dose- and time-dependent manner. Also, quercetin inhibited the proliferation of PC cells and the growth of xenograft tumors |
Pubmed ID | 32210615 |
Year | 2020 |
Title | Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1 |
External Links
Links for MALAT1 | GenBank HGNC NONCODE |
Links for prostate cancer | OMIM COSMIC |