Basic Information
| LncRNA/CircRNA Name | ATXN8OS |
| Synonyms | NA |
| Region | GRCh38_13:70107213-70139429 |
| Ensemble | ENSG00000230223 |
| Refseq | NR_002717 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | human BC and matched non-tumour tissues,normal breast epithelial cell line(MCF-10A),human BC cell lines(MCF7 and MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | ATXN8OS was markedly up-regulated in BC tissue and cell lines, and that its level of overexpression was inversely linked with the overall survival rate of patients with BC.Knockdown of ATXN8OS inhibited proliferation, viability and invasion in the human BC cell lines.In addition, microRNA-204 (miR-204) was negatively associated with the expression of ATXN8OS in BC tissues and cell lines.A luciferase assay demonstrated a direct binding site for miR-204 within ATXN8OS, and inhibition of miR-204 stimulated the tumour-promoting effect of ATXN8OS on BC cells. |
| Pubmed ID | 31173245 |
| Year | 2019 |
| Title | lncRNA ATXN8OS Promotes Breast Cancer by Sequestering miR-204 |
External Links
| Links for ATXN8OS | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |