Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR |
| Sample | ovarian cancer cell lines (OVCAR-3) |
| Expression Pattern | up-regulated |
| Function Description | The expression lev-els of lncRNA Malat-1 in OVCAR-3 cells treated with different doses of rosmarinic acid were con-siderably higher than that in adjacent non-tumor tissues as well as cancer cells without any drug treatment. Rosmarinic acid induced potent anticancer effects in OCVAR- 3 cancer cells by inducing apoptosis, inhibiting cell migration and modulating lncRNA Malat-1 expression. |
| Pubmed ID | 30003749 |
| Year | 2018 |
| Title | Anticancer Effects of Rosmarinic Acid in OVCAR-3 Ovarian Cancer Cells Are Mediated via Induction of Apoptosis, Suppression of Cell Migration and Modulation of lncRNA MALAT-1 Expression |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |