Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR |
| Sample | breast cancer tissues, cell lines (HEK-293T and MDA-MB-231) |
| Expression Pattern | down-regulated |
| Function Description | Malat1 is reduced in both ductal and lobular breast cancer morphological subtypes compared to control normal breast tissue. Moreover, increased levels of both Malat1 and Nischarin were found to positively correlate with enhanced patient recurrence-free survival. Using these cells, we assess how the link between Nischarin and Malat1 affects cancer cell function, finding that Malat1 confers an inhibitory effect on cell growth and migration which is lost following Malat1 KO, but in a Nisch-dependent context. Specifically, Malat1 KO in the background of low Nischarin expression had a limited effect on cell functions, while Malat1 KO in cells with high levels of Nischarin led to significant increases in cell proliferation and migration. |
| Pubmed ID | 29912916 |
| Year | 2018 |
| Title | Expression of Long Noncoding RNA MALAT1 Correlates With Increased Levels of Nischarin and Inhibits Oncogenic Cell Functions in Breast Cancer |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |