Basic Information
| LncRNA/CircRNA Name | MALAT1 |
| Synonyms | NA |
| Region | GRCh38_11:65497688-65506516 |
| Ensemble | ENSG00000251562 |
| Refseq | NR_002819 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot |
| Sample | ovarian cancer tissues, cell lines(KOV3, OVCAR3, 3AO and HO8910) |
| Expression Pattern | up-regulated |
| Function Description | The relative expression level of MALAT1 was identified to be aberrantly up-regulated in ovarian cancer tissues and cell lines. The expression level of MALAT1 in ovarian cancer with metastasis was increased compared with ovarian cancer without metastasis. The high expression level of MALAT1 was associated with poor prognosis in ovarian cancer patients. The down-regulation of MALAT1 inhibited cell proliferation, invasion and migration, arrested cell cycle progression in S phase and induced cell apoptosis in ovarian cancer cell lines. Meanwhile, the down-regulation of MALAT1 decreased the expression level of DVL2, ?-catenin and cyclin D1 and increased the expression level of GSK-3? in SKOV3 and HO8910 cells. Moreover, the inhibitory effect of MALAT1 down-regulation in cell invasion and migration was reversed by SKL2001 activating Wnt/?-catenin signal pathway and enhanced by XAV939 inhibiting Wnt/?-catenin signal pathway. |
| Pubmed ID | 29949143 |
| Year | 2018 |
| Title | Long Non-Coding RNA MALAT1 Regulates Ovarian Cancer Cell Proliferation, Migration and Apoptosis Through Wnt/?-catenin Signaling Pathway |
External Links
| Links for MALAT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |