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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	qPCR, Western blot, in vitro knockdown, RNAi
Sample	colorectal cancer tissues, cell lines (SW480 and SW620)
Expression Pattern	up-regulated
Function Description	We found that the DCP1A expression level in tumors was significantly higher than those in the corresponding normal tissues. The survival statistics showed that for CRC patients with T3 and T4 stages,higher DCP1A levels experienced significantly decreased the survival expectancy than patients with lower DCP1A, suggesting that DCP1A may be involved in the generation and development of colorectal cancer and is related with poorer prognosis. We found that DCP1A is a direct target molecule of MALAT1. Moreover, by screening the downstream genes of MALAT1, we noticed that microRNA 203(miR203), an oncogene suppressor in numerous cancers, is inversely correlated to both MALAT1 and DCP1A expressions. Following MALAT1 knockdown, we observed overexpression of miR203 accompanied with DCP1A downregulation to a level that reversed the promoted cell proliferation, invasion, and migration in vitro and in vivo, which could be restored by miR203 knockdown or DCP1A overexpression.
Pubmed ID	29964337
Year	2018
Title	MALAT1 Promotes the Colorectal Cancer Malignancy by Increasing DCP1A Expression and miR203 Downregulation

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