Basic Information
| LncRNA/CircRNA Name | MAGI2-AS3 |
| Synonyms | NA |
| Region | GRCh38_7:79452877-79471208 |
| Ensemble | ENSG00000234456 |
| Refseq | NR_038343 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, etc. |
| Sample | blood |
| Expression Pattern | down-regulated |
| Function Description | MAGI2-AS3 level significantly correlated with tumor-node-metastasis (TNM) stage (p=0.001 in TEPs, p=0.003 in plasma), lymph-node metastasis (p=0.016 in TEPs, p=0.023 in plasma), and distant metastasis (p=0.045 in TEPs, p=0.045 in plasma). Our data suggested that EGFRvIII can also be detected in blood platelets and there was no difference with detection in plasma. EGFRvIII RNA existed in both TEPs and plasma, but EGFR intracellular mutations cannot be detected in DNA of TEPs isolated from NSCLC. |
| Pubmed ID | 29922089 |
| Year | 2018 |
| Title | LncRNAs and EGFRvIII sequestered in TEPs enable blood-based NSCLC diagnosis. |
External Links
| Links for MAGI2-AS3 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |